Drug interactions
Hydrocortisone + Nimodipine
Severity: Minor
Hydrocortisone and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer at most, so a clinically meaningful drop in nimodipine levels is not well established. The practical impact is likely small.
What this interaction means in plain words
Hydrocortisone and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Nimodipine belongs to Cardiovascular.
Why it happens
Possible weak induction of CYP3A4 by corticosteroids, not well established for hydrocortisone.
What to do
No routine adjustment is needed; monitor blood pressure and clinical response to nimodipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Hydrocortisone with Nimodipine?
MediHelp rates the interaction as minor. Hydrocortisone and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is a weak CYP3A4 inducer at most, so a clinically meaningful drop in nimodipine levels is not well established. The practical impact is likely small.
How serious is the interaction between Hydrocortisone and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and clinical response to nimodipine.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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