Drug interactions
Hydrocortisone + Paclitaxel
Severity: Minor
Hydrocortisone and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids are commonly given with paclitaxel as premedication to prevent hypersensitivity reactions. No clinically important pharmacokinetic interaction through CYP3A4 is established for hydrocortisone.
What this interaction means in plain words
Hydrocortisone and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Paclitaxel belongs to Oncology.
Why it happens
Possible weak CYP3A4 induction by corticosteroids; not clinically established.
What to do
No dose adjustment is needed; follow the usual premedication protocol and monitor blood glucose and counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Hydrocortisone with Paclitaxel?
MediHelp rates the interaction as minor. Hydrocortisone and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids are commonly given with paclitaxel as premedication to prevent hypersensitivity reactions. No clinically important pharmacokinetic interaction through CYP3A4 is established for hydrocortisone.
How serious is the interaction between Hydrocortisone and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; follow the usual premedication protocol and monitor blood glucose and counts.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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