Drug interactions
Hydrocortisone + Propafenone
Severity: Minor
Hydrocortisone and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established clinically significant interaction exists. Hydrocortisone-induced hypokalemia could theoretically increase proarrhythmic risk with propafenone.
What this interaction means in plain words
Hydrocortisone and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Propafenone belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 induction; steroid-induced hypokalemia may add to arrhythmia risk.
What to do
Check potassium during prolonged or high-dose steroid therapy and correct deficits.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Hydrocortisone with Propafenone?
MediHelp rates the interaction as minor. Hydrocortisone and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established clinically significant interaction exists. Hydrocortisone-induced hypokalemia could theoretically increase proarrhythmic risk with propafenone.
How serious is the interaction between Hydrocortisone and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium during prolonged or high-dose steroid therapy and correct deficits.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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