Drug interactions
Hydrocortisone + Repaglinide
Severity: Moderate
Hydrocortisone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and antagonize antidiabetic therapy, and they may also weakly induce CYP3A4 and lower repaglinide levels. Together these may reduce glycemic control.
What this interaction means in plain words
Hydrocortisone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic glucose-raising effect of hydrocortisone plus possible weak CYP3A4 induction of repaglinide metabolism.
What to do
Monitor blood glucose more frequently when starting or increasing hydrocortisone and adjust the repaglinide dose as needed. Watch for hypoglycemia when steroids are tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Hydrocortisone with Repaglinide?
MediHelp rates the interaction as moderate. Hydrocortisone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and antagonize antidiabetic therapy, and they may also weakly induce CYP3A4 and lower repaglinide levels. Together these may reduce glycemic control.
How serious is the interaction between Hydrocortisone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or increasing hydrocortisone and adjust the repaglinide dose as needed. Watch for hypoglycemia when steroids are tapered.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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