Drug interactions
Hydrocortisone + Sarecycline
Severity: Minor
Hydrocortisone and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is reported to inhibit P-glycoprotein in vitro, which could in theory increase hydrocortisone exposure. Systemic exposure to sarecycline is modest and a clinically meaningful change in hydrocortisone effect is unlikely.
What this interaction means in plain words
Hydrocortisone and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by sarecycline reducing hydrocortisone efflux.
What to do
No routine adjustment is needed. Be alert for signs of glucocorticoid excess in patients on long-term or high-dose hydrocortisone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Hydrocortisone with Sarecycline?
MediHelp rates the interaction as minor. Hydrocortisone and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is reported to inhibit P-glycoprotein in vitro, which could in theory increase hydrocortisone exposure. Systemic exposure to sarecycline is modest and a clinically meaningful change in hydrocortisone effect is unlikely.
How serious is the interaction between Hydrocortisone and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Be alert for signs of glucocorticoid excess in patients on long-term or high-dose hydrocortisone.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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