Drug interactions
Hydrocortisone + Saxagliptin-metformin
Severity: Moderate
Hydrocortisone and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids raise blood glucose and can offset the glucose-lowering effect of saxagliptin and metformin. Patients with diabetes may develop hyperglycemia, especially with higher doses or prolonged courses.
What this interaction means in plain words
Hydrocortisone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Corticosteroids increase hepatic gluconeogenesis and peripheral insulin resistance, opposing the effects of antidiabetic agents.
What to do
Monitor blood glucose more frequently when starting, increasing or stopping hydrocortisone, and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Hydrocortisone and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids raise blood glucose and can offset the glucose-lowering effect of saxagliptin and metformin. Patients with diabetes may develop hyperglycemia, especially with higher doses or prolonged courses.
How serious is the interaction between Hydrocortisone and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, increasing or stopping hydrocortisone, and adjust the antidiabetic regimen as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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