Drug interactions
Hydrocortisone + Sufentanil
Severity: Minor
Hydrocortisone and Sufentanil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a CYP3A4 substrate and hydrocortisone is a weak potential inducer, so analgesic effect could be slightly reduced. The effect is unlikely to be clinically important.
What this interaction means in plain words
Hydrocortisone and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Sufentanil belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone increasing sufentanil metabolism.
What to do
No routine adjustment; titrate sufentanil to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Hydrocortisone with Sufentanil?
MediHelp rates the interaction as minor. Hydrocortisone and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sufentanil is a CYP3A4 substrate and hydrocortisone is a weak potential inducer, so analgesic effect could be slightly reduced. The effect is unlikely to be clinically important.
How serious is the interaction between Hydrocortisone and Sufentanil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; titrate sufentanil to clinical response.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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