Drug interactions
Hydrocortisone + Tolazamide
Severity: Moderate
Hydrocortisone and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone raises blood glucose through increased gluconeogenesis and insulin resistance, opposing the glucose-lowering effect of tolazamide. Hyperglycemia may emerge, especially with systemic or prolonged corticosteroid use.
What this interaction means in plain words
Hydrocortisone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoid-induced hepatic glucose output and peripheral insulin resistance counter sulfonylurea action.
What to do
Monitor blood glucose when systemic hydrocortisone is started, changed or stopped, and increase the tolazamide dose or add therapy as needed; reduce the dose again when the steroid is withdrawn to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Hydrocortisone with Tolazamide?
MediHelp rates the interaction as moderate. Hydrocortisone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone raises blood glucose through increased gluconeogenesis and insulin resistance, opposing the glucose-lowering effect of tolazamide. Hyperglycemia may emerge, especially with systemic or prolonged corticosteroid use.
How serious is the interaction between Hydrocortisone and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when systemic hydrocortisone is started, changed or stopped, and increase the tolazamide dose or add therapy as needed; reduce the dose again when the steroid is withdrawn to avoid hypoglycemia.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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