Drug interactions
Hydrocortisone + Zafirlukast
Severity: Minor
Hydrocortisone and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast may slightly reduce hydrocortisone clearance, but the effect is expected to be small. Any increase in corticosteroid exposure is unlikely to matter clinically in most patients.
What this interaction means in plain words
Hydrocortisone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Theoretical weak CYP3A4 inhibition by zafirlukast reducing hydrocortisone metabolism.
What to do
No routine change is needed. Watch for signs of corticosteroid excess such as fluid retention or hyperglycemia if high doses or prolonged courses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Zafirlukast?
MediHelp rates the interaction as minor. Hydrocortisone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast may slightly reduce hydrocortisone clearance, but the effect is expected to be small. Any increase in corticosteroid exposure is unlikely to matter clinically in most patients.
How serious is the interaction between Hydrocortisone and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for signs of corticosteroid excess such as fluid retention or hyperglycemia if high doses or prolonged courses are used.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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