Drug interactions
Hydrocortisone + Ziprasidone
Severity: Minor
Hydrocortisone and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may weakly induce CYP3A4, which could slightly reduce ziprasidone levels, though CYP3A4 is only a minor route for it. Corticosteroid-related hypokalemia may separately add to QT risk.
What this interaction means in plain words
Hydrocortisone and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone; ziprasidone is mainly cleared by aldehyde oxidase.
What to do
No dose change is usually needed; check potassium and magnesium if prolonged systemic steroids are used with ziprasidone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Hydrocortisone with Ziprasidone?
MediHelp rates the interaction as minor. Hydrocortisone and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may weakly induce CYP3A4, which could slightly reduce ziprasidone levels, though CYP3A4 is only a minor route for it. Corticosteroid-related hypokalemia may separately add to QT risk.
How serious is the interaction between Hydrocortisone and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; check potassium and magnesium if prolonged systemic steroids are used with ziprasidone.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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