Drug interactions
Hydroxyprogesterone caproate + Prednisone
Severity: Minor
Hydroxyprogesterone caproate and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone is not a meaningful CYP3A4 inducer, so a reduction in hydroxyprogesterone levels is unlikely. Both can contribute to fluid retention and glucose intolerance.
What this interaction means in plain words
Hydroxyprogesterone caproate and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established pharmacokinetic mechanism; additive glucocorticoid-related effects are possible.
What to do
No adjustment is needed; monitor blood glucose and fluid status in at-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Prednisone?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prednisone is not a meaningful CYP3A4 inducer, so a reduction in hydroxyprogesterone levels is unlikely. Both can contribute to fluid retention and glucose intolerance.
How serious is the interaction between Hydroxyprogesterone caproate and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor blood glucose and fluid status in at-risk patients.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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