Drug interactions
Hydroxyprogesterone caproate + Secobarbital
Severity: Moderate
Hydroxyprogesterone caproate and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce hydroxyprogesterone caproate exposure through enzyme induction, potentially lowering its effect.
What this interaction means in plain words
Hydroxyprogesterone caproate and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases progestin metabolism.
What to do
Monitor clinical response to hydroxyprogesterone caproate. Consider a non-inducing sedative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Secobarbital?
MediHelp rates the interaction as moderate. Hydroxyprogesterone caproate and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may reduce hydroxyprogesterone caproate exposure through enzyme induction, potentially lowering its effect.
How serious is the interaction between Hydroxyprogesterone caproate and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to hydroxyprogesterone caproate. Consider a non-inducing sedative.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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