Drug interactions
Hydroxyprogesterone caproate + Zafirlukast
Severity: Minor
Hydroxyprogesterone caproate and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast may slightly increase hydroxyprogesterone caproate exposure through CYP3A4 inhibition. The clinical impact is expected to be minimal.
What this interaction means in plain words
Hydroxyprogesterone caproate and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by zafirlukast reduces metabolism of the progestin.
What to do
No action is generally needed beyond routine monitoring for progestin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Zafirlukast?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast may slightly increase hydroxyprogesterone caproate exposure through CYP3A4 inhibition. The clinical impact is expected to be minimal.
How serious is the interaction between Hydroxyprogesterone caproate and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed beyond routine monitoring for progestin adverse effects.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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