Drug interactions
Hydroxyurea + Ifosfamide
Severity: Moderate
Hydroxyurea and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function, so combined use can cause deeper cytopenias and increased infection or bleeding risk.
What this interaction means in plain words
Hydroxyurea and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Ifosfamide belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts closely and reduce doses or delay therapy when counts fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Ifosfamide?
MediHelp rates the interaction as moderate. Hydroxyurea and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function, so combined use can cause deeper cytopenias and increased infection or bleeding risk.
How serious is the interaction between Hydroxyurea and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and reduce doses or delay therapy when counts fall.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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