Drug interactions
Hydroxyurea + Measles mumps and rubella vaccine
Severity: Major
Hydroxyurea and Measles mumps and rubella vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyurea is myelosuppressive and may impair immune function, so live vaccine virus may replicate excessively. Vaccine efficacy may also be reduced.
What this interaction means in plain words
Hydroxyurea and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyurea belongs to Miscellaneous; Measles mumps and rubella vaccine belongs to Miscellaneous.
Why it happens
Cytotoxic myelosuppression and immunosuppression impair control of live attenuated virus.
What to do
Avoid live vaccines during hydroxyurea therapy unless benefit clearly outweighs risk and specialist advice supports it. Use inactivated vaccines where available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Measles mumps and rubella vaccine?
MediHelp rates the interaction as major. Hydroxyurea and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydroxyurea is myelosuppressive and may impair immune function, so live vaccine virus may replicate excessively. Vaccine efficacy may also be reduced.
How serious is the interaction between Hydroxyurea and Measles mumps and rubella vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during hydroxyurea therapy unless benefit clearly outweighs risk and specialist advice supports it. Use inactivated vaccines where available.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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