Drug interactions
Albuterol + Hydroxyzine
Severity: Moderate
Albuterol and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydroxyzine and high doses of albuterol can prolong the QT interval or cause hypokalemia, which could increase arrhythmia risk in susceptible patients. Albuterol may cause stimulation that partly offsets hydroxyzine sedation.
What this interaction means in plain words
Albuterol and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist induced hypokalemia contributing, plus opposing CNS effects.
What to do
Check potassium and consider an ECG in patients with other QT risk factors, cardiac disease or high doses of albuterol. Use the lowest effective hydroxyzine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Albuterol with Hydroxyzine?
MediHelp rates the interaction as moderate. Albuterol and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydroxyzine and high doses of albuterol can prolong the QT interval or cause hypokalemia, which could increase arrhythmia risk in susceptible patients. Albuterol may cause stimulation that partly offsets hydroxyzine sedation.
How serious is the interaction between Albuterol and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and consider an ECG in patients with other QT risk factors, cardiac disease or high doses of albuterol. Use the lowest effective hydroxyzine dose.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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