Drug interactions
Hyoscyamine spray + Umeclidinium-vilanterol
Severity: Moderate
Hyoscyamine spray and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine oral spray is absorbed systemically and adds to the anticholinergic activity of inhaled umeclidinium. The combination can increase dry mouth, constipation, urinary retention, blurred vision and tachycardia.
What this interaction means in plain words
Hyoscyamine spray and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Avoid combined use where possible and monitor for urinary retention, constipation and worsening glaucoma. Reduce the hyoscyamine dose or stop it if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Hyoscyamine spray with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Hyoscyamine spray and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine oral spray is absorbed systemically and adds to the anticholinergic activity of inhaled umeclidinium. The combination can increase dry mouth, constipation, urinary retention, blurred vision and tachycardia.
How serious is the interaction between Hyoscyamine spray and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible and monitor for urinary retention, constipation and worsening glaucoma. Reduce the hyoscyamine dose or stop it if symptoms appear.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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