Drug interactions
Hyoscyamine spray + Ziprasidone
Severity: Moderate
Hyoscyamine spray and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine given as an oral spray is absorbed systemically and has antimuscarinic effects that can add to the mild anticholinergic activity of ziprasidone. This may cause dry mouth, constipation, urinary retention and confusion.
What this interaction means in plain words
Hyoscyamine spray and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects, particularly in older patients. Reduce the hyoscyamine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Hyoscyamine spray with Ziprasidone?
MediHelp rates the interaction as moderate. Hyoscyamine spray and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine given as an oral spray is absorbed systemically and has antimuscarinic effects that can add to the mild anticholinergic activity of ziprasidone. This may cause dry mouth, constipation, urinary retention and confusion.
How serious is the interaction between Hyoscyamine spray and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly in older patients. Reduce the hyoscyamine dose if they occur.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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