Drug interactions
Ibrexafungerp + Vardenafil
Severity: Minor
Ibrexafungerp and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrexafungerp is a CYP3A4 substrate with some inhibitory activity on CYP3A4, which may modestly raise vardenafil concentrations. This could increase hypotension and other vardenafil adverse effects.
What this interaction means in plain words
Ibrexafungerp and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP3A4 by ibrexafungerp reducing vardenafil metabolism.
What to do
Monitor for hypotension, headache and dizziness, and consider a lower vardenafil dose if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Ibrexafungerp with Vardenafil?
MediHelp rates the interaction as minor. Ibrexafungerp and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibrexafungerp is a CYP3A4 substrate with some inhibitory activity on CYP3A4, which may modestly raise vardenafil concentrations. This could increase hypotension and other vardenafil adverse effects.
How serious is the interaction between Ibrexafungerp and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hypotension, headache and dizziness, and consider a lower vardenafil dose if symptomatic.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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