Drug interactions
Ibritumomab tiuxetan + Zidovudine
Severity: Major
Ibritumomab tiuxetan and Zidovudine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibritumomab tiuxetan causes prolonged and sometimes severe cytopenias, and zidovudine also suppresses bone marrow. Combined use may increase the severity and duration of neutropenia, anemia and thrombocytopenia.
What this interaction means in plain words
Ibritumomab tiuxetan and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive myelosuppression from radioimmunotherapy and zidovudine.
What to do
Consider substituting a less myelotoxic antiretroviral for zidovudine around ibritumomab therapy. Monitor complete blood counts at least weekly until recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Ibritumomab tiuxetan with Zidovudine?
MediHelp rates the interaction as major. Ibritumomab tiuxetan and Zidovudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibritumomab tiuxetan causes prolonged and sometimes severe cytopenias, and zidovudine also suppresses bone marrow. Combined use may increase the severity and duration of neutropenia, anemia and thrombocytopenia.
How serious is the interaction between Ibritumomab tiuxetan and Zidovudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider substituting a less myelotoxic antiretroviral for zidovudine around ibritumomab therapy. Monitor complete blood counts at least weekly until recovery.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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