Drug interactions
Ibrutinib + Naproxen
Severity: Moderate
Ibrutinib and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and carries a bleeding risk, which may be increased by NSAIDs that also inhibit platelets and irritate the gastric mucosa. Serious hemorrhage has been reported with ibrutinib, especially alongside antithrombotic agents.
What this interaction means in plain words
Ibrutinib and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Naproxen belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function through BTK inhibition by ibrutinib and cyclooxygenase inhibition by naproxen.
What to do
Avoid regular NSAID use where possible and monitor for signs of bleeding. Consider gastroprotection and use paracetamol as an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Naproxen?
MediHelp rates the interaction as moderate. Ibrutinib and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and carries a bleeding risk, which may be increased by NSAIDs that also inhibit platelets and irritate the gastric mucosa. Serious hemorrhage has been reported with ibrutinib, especially alongside antithrombotic agents.
How serious is the interaction between Ibrutinib and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and monitor for signs of bleeding. Consider gastroprotection and use paracetamol as an alternative analgesic.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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