Drug interactions
Ibrutinib + Oxcarbazepine
Severity: Major
Ibrutinib and Oxcarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can lower ibrutinib exposure through weak-to-moderate CYP3A induction. Reduced ibrutinib concentrations may lead to loss of antineoplastic efficacy.
What this interaction means in plain words
Ibrutinib and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibrutinib belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by oxcarbazepine (and its active metabolite) increases first-pass and hepatic metabolism of ibrutinib.
What to do
Prefer an anticonvulsant with no CYP3A induction, such as levetiracetam. If it must be combined, monitor closely for reduced ibrutinib response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Oxcarbazepine?
MediHelp rates the interaction as major. Ibrutinib and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine can lower ibrutinib exposure through weak-to-moderate CYP3A induction. Reduced ibrutinib concentrations may lead to loss of antineoplastic efficacy.
How serious is the interaction between Ibrutinib and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an anticonvulsant with no CYP3A induction, such as levetiracetam. If it must be combined, monitor closely for reduced ibrutinib response.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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