Drug interactions
Ibrutinib + Tirofiban
Severity: Major
Ibrutinib and Tirofiban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and is associated with serious hemorrhage. Combined with tirofiban, bleeding risk is likely increased.
What this interaction means in plain words
Ibrutinib and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibrutinib belongs to Oncology; Tirofiban belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic platelet inhibition (BTK inhibition plus GP IIb/IIIa blockade).
What to do
Avoid if possible, or consider temporarily holding ibrutinib around the procedure. If combined, monitor closely for bleeding, hemoglobin and platelet count.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tirofiban
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Tirofiban?
MediHelp rates the interaction as major. Ibrutinib and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibrutinib impairs platelet function and is associated with serious hemorrhage. Combined with tirofiban, bleeding risk is likely increased.
How serious is the interaction between Ibrutinib and Tirofiban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or consider temporarily holding ibrutinib around the procedure. If combined, monitor closely for bleeding, hemoglobin and platelet count.
What other medicines interact with Tirofiban?
MediHelp also lists interactions of Tirofiban with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Tirofiban page.
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