Drug interactions
Ibrutinib + Tolmetin
Severity: Moderate
Ibrutinib and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and carries a bleeding risk, and tolmetin also inhibits platelets and irritates the gastric mucosa. Together they may increase the risk of bleeding, including gastrointestinal hemorrhage.
What this interaction means in plain words
Ibrutinib and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects: BTK inhibition by ibrutinib and reversible COX-1 inhibition by tolmetin.
What to do
Monitor for signs of bleeding and check blood counts periodically. Consider acetaminophen or another alternative for analgesia, and add gastroprotection if the NSAID is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Tolmetin?
MediHelp rates the interaction as moderate. Ibrutinib and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and carries a bleeding risk, and tolmetin also inhibits platelets and irritates the gastric mucosa. Together they may increase the risk of bleeding, including gastrointestinal hemorrhage.
How serious is the interaction between Ibrutinib and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check blood counts periodically. Consider acetaminophen or another alternative for analgesia, and add gastroprotection if the NSAID is needed.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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