Drug interactions
Ibrutinib + Trastuzumab
Severity: Moderate
Ibrutinib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can contribute to neutropenia and infection risk, and ibrutinib also carries risks of atrial fibrillation and bleeding. Trastuzumab can cause cardiac dysfunction, so cardiac monitoring is also relevant when combined.
What this interaction means in plain words
Ibrutinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive effects, with potential overlapping cardiac toxicity.
What to do
Monitor blood counts, cardiac function and heart rhythm, and assess promptly for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Trastuzumab?
MediHelp rates the interaction as moderate. Ibrutinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can contribute to neutropenia and infection risk, and ibrutinib also carries risks of atrial fibrillation and bleeding. Trastuzumab can cause cardiac dysfunction, so cardiac monitoring is also relevant when combined.
How serious is the interaction between Ibrutinib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, cardiac function and heart rhythm, and assess promptly for infection.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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