Drug interactions
Ibuprofen + Moexipril
Severity: Moderate
Ibuprofen and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the antihypertensive effect of moexipril. The combination may also impair renal function, particularly in elderly, dehydrated or renally impaired patients.
What this interaction means in plain words
Ibuprofen and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Moexipril belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal vasodilatory prostaglandins opposes ACE inhibitor effects and reduces glomerular perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or changing the NSAID, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest time or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Ibuprofen with Moexipril?
MediHelp rates the interaction as moderate. Ibuprofen and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce the antihypertensive effect of moexipril. The combination may also impair renal function, particularly in elderly, dehydrated or renally impaired patients.
How serious is the interaction between Ibuprofen and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or changing the NSAID, and keep the patient well hydrated. Use the lowest effective NSAID dose for the shortest time or choose paracetamol.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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