Drug interactions
Ibuprofen + Nateglinide
Severity: Minor
Ibuprofen and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide is a CYP2C9 substrate and ibuprofen is also metabolized by this enzyme, so competition is theoretically possible. Evidence of a clinically relevant change in ibuprofen exposure is lacking.
What this interaction means in plain words
Ibuprofen and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Nateglinide belongs to Endocrine.
Why it happens
Theoretical competition for CYP2C9 metabolism.
What to do
No dose adjustment is required. Monitor blood glucose as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Ibuprofen with Nateglinide?
MediHelp rates the interaction as minor. Ibuprofen and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nateglinide is a CYP2C9 substrate and ibuprofen is also metabolized by this enzyme, so competition is theoretically possible. Evidence of a clinically relevant change in ibuprofen exposure is lacking.
How serious is the interaction between Ibuprofen and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor blood glucose as usual.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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