Drug interactions
Ibuprofen + Nilotinib
Severity: Minor
Ibuprofen and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP2C9 in vitro and might modestly raise ibuprofen exposure. NSAIDs can also add to bleeding risk in patients with nilotinib-related thrombocytopenia.
What this interaction means in plain words
Ibuprofen and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Possible inhibition of CYP2C9-mediated ibuprofen metabolism by nilotinib.
What to do
No dose change is required. Monitor platelet counts and for bleeding or GI effects during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Ibuprofen with Nilotinib?
MediHelp rates the interaction as minor. Ibuprofen and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP2C9 in vitro and might modestly raise ibuprofen exposure. NSAIDs can also add to bleeding risk in patients with nilotinib-related thrombocytopenia.
How serious is the interaction between Ibuprofen and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor platelet counts and for bleeding or GI effects during combined use.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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