Drug interactions
Ibuprofen + Oxacillin
Severity: Minor
Ibuprofen and Oxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may reduce renal tubular secretion of penicillins and compete for protein binding, which could modestly raise oxacillin exposure. Clinical consequences are usually small at standard doses.
What this interaction means in plain words
Ibuprofen and Oxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Oxacillin belongs to Anti Bacterial.
Why it happens
Competition for renal tubular anionic secretion and plasma protein binding.
What to do
No routine adjustment is needed; monitor renal function in patients on high-dose oxacillin with an NSAID.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxacillin
- Bcg vaccine live + Oxacillin Moderate
- Chloramphenicol + Oxacillin Moderate
- Cholera vaccine + Oxacillin Moderate
- Demeclocycline + Oxacillin Moderate
- Doxycycline + Oxacillin Moderate
- Microbiota + Oxacillin Moderate
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Oxacillin?
MediHelp rates the interaction as minor. Ibuprofen and Oxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibuprofen may reduce renal tubular secretion of penicillins and compete for protein binding, which could modestly raise oxacillin exposure. Clinical consequences are usually small at standard doses.
How serious is the interaction between Ibuprofen and Oxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function in patients on high-dose oxacillin with an NSAID.
What other medicines interact with Oxacillin?
MediHelp also lists interactions of Oxacillin with, for example, Bcg vaccine live, Chloramphenicol, Cholera vaccine. The full list is on the Oxacillin page.
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