Drug interactions
Ibuprofen + Paroxetine
Severity: Moderate
Ibuprofen and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine reduces platelet serotonin content and ibuprofen inhibits platelet function and injures gastric mucosa. Combined use markedly increases the likelihood of upper GI bleeding.
What this interaction means in plain words
Ibuprofen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet aggregation together with NSAID-induced mucosal injury.
What to do
Avoid long-term combination where possible; if needed, add a proton pump inhibitor in at-risk patients and watch for GI bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Ibuprofen with Paroxetine?
MediHelp rates the interaction as moderate. Ibuprofen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine reduces platelet serotonin content and ibuprofen inhibits platelet function and injures gastric mucosa. Combined use markedly increases the likelihood of upper GI bleeding.
How serious is the interaction between Ibuprofen and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination where possible; if needed, add a proton pump inhibitor in at-risk patients and watch for GI bleeding signs.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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