Drug interactions
Ibuprofen + Pneumococcal polysaccharide conjugate vaccine
Severity: Minor
Ibuprofen and Pneumococcal polysaccharide conjugate vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prophylactic antipyretics given around the time of infant vaccination have been linked to somewhat lower antibody responses to some antigens. The clinical significance is uncertain, and protection generally remains adequate.
What this interaction means in plain words
Ibuprofen and Pneumococcal polysaccharide conjugate vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Pneumococcal polysaccharide conjugate vaccine belongs to Miscellaneous.
Why it happens
Possible dampening of the early inflammatory and immune response to vaccination; the mechanism is not firmly established.
What to do
Avoid routine prophylactic ibuprofen at vaccination, but treat fever or pain when it occurs. Do not delay or withhold vaccination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pneumococcal polysaccharide conjugate vaccine
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Pneumococcal polysaccharide conjugate vaccine?
MediHelp rates the interaction as minor. Ibuprofen and Pneumococcal polysaccharide conjugate vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prophylactic antipyretics given around the time of infant vaccination have been linked to somewhat lower antibody responses to some antigens. The clinical significance is uncertain, and protection generally remains adequate.
How serious is the interaction between Ibuprofen and Pneumococcal polysaccharide conjugate vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine prophylactic ibuprofen at vaccination, but treat fever or pain when it occurs. Do not delay or withhold vaccination.
What other medicines interact with Pneumococcal polysaccharide conjugate vaccine?
MediHelp also lists interactions of Pneumococcal polysaccharide conjugate vaccine with, for example, Paracetamol. The full list is on the Pneumococcal polysaccharide conjugate vaccine page.
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