Drug interactions
Paracetamol + Pneumococcal polysaccharide conjugate vaccine
Severity: Minor
Paracetamol and Pneumococcal polysaccharide conjugate vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prophylactic paracetamol given around infant vaccination has been associated with somewhat lower antibody responses to some vaccine antigens. The clinical significance is uncertain, and protective responses are generally still achieved.
What this interaction means in plain words
Paracetamol and Pneumococcal polysaccharide conjugate vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paracetamol belongs to Musculoskeletal; Pneumococcal polysaccharide conjugate vaccine belongs to Miscellaneous.
Why it happens
Possible blunting of the early inflammatory response to vaccination; the mechanism is not firmly established.
What to do
Avoid routine prophylactic paracetamol at vaccination, but use it to treat fever or discomfort when needed. Do not delay or withhold vaccination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pneumococcal polysaccharide conjugate vaccine
Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Felbamate + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
Frequently asked questions
Can I take Paracetamol with Pneumococcal polysaccharide conjugate vaccine?
MediHelp rates the interaction as minor. Paracetamol and Pneumococcal polysaccharide conjugate vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prophylactic paracetamol given around infant vaccination has been associated with somewhat lower antibody responses to some vaccine antigens. The clinical significance is uncertain, and protective responses are generally still achieved.
How serious is the interaction between Paracetamol and Pneumococcal polysaccharide conjugate vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine prophylactic paracetamol at vaccination, but use it to treat fever or discomfort when needed. Do not delay or withhold vaccination.
What other medicines interact with Pneumococcal polysaccharide conjugate vaccine?
MediHelp also lists interactions of Pneumococcal polysaccharide conjugate vaccine with, for example, Ibuprofen. The full list is on the Pneumococcal polysaccharide conjugate vaccine page.
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