Drug interactions
Ibuprofen + Primidone
Severity: Minor
Ibuprofen and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is partly converted to phenobarbital and acts as an enzyme inducer, so it may slightly reduce ibuprofen exposure. Loss of analgesic effect is possible but rarely important.
What this interaction means in plain words
Ibuprofen and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Primidone belongs to Central Nervous System.
Why it happens
Primidone and its metabolite phenobarbital induce hepatic enzymes including CYP2C9, increasing ibuprofen clearance.
What to do
No routine adjustment is needed; reassess pain relief and titrate the ibuprofen dose within labeled limits if the response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Ibuprofen with Primidone?
MediHelp rates the interaction as minor. Ibuprofen and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is partly converted to phenobarbital and acts as an enzyme inducer, so it may slightly reduce ibuprofen exposure. Loss of analgesic effect is possible but rarely important.
How serious is the interaction between Ibuprofen and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess pain relief and titrate the ibuprofen dose within labeled limits if the response is poor.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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