Drug interactions
Ibuprofen + Sacubitril-valsartan
Severity: Major
Ibuprofen and Sacubitril-valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin synthesis, which can impair kidney function in patients taking sacubitril-valsartan, especially those who are elderly or volume depleted. They may also blunt the blood pressure and heart failure benefits and increase the risk of hyperkalemia and fluid retention.
What this interaction means in plain words
Ibuprofen and Sacubitril-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibuprofen belongs to Musculoskeletal; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins reduces renal perfusion and sodium excretion, which combined with angiotensin receptor blockade impairs glomerular filtration and raises potassium.
What to do
Avoid regular NSAID use and prefer paracetamol for analgesia. If an NSAID is unavoidable, use the lowest dose for the shortest time and monitor creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Sacubitril-valsartan?
MediHelp rates the interaction as major. Ibuprofen and Sacubitril-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs reduce renal prostaglandin synthesis, which can impair kidney function in patients taking sacubitril-valsartan, especially those who are elderly or volume depleted. They may also blunt the blood pressure and heart failure benefits and increase the risk of hyperkalemia and fluid retention.
How serious is the interaction between Ibuprofen and Sacubitril-valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use and prefer paracetamol for analgesia. If an NSAID is unavoidable, use the lowest dose for the shortest time and monitor creatinine, potassium and blood pressure.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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