Drug interactions
Ibuprofen + Siponimod
Severity: Minor
Ibuprofen and Siponimod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen is a substrate and weak inhibitor of CYP2C9, so a clinically meaningful rise in siponimod exposure is unlikely. Siponimod interaction concerns are significant mainly with moderate or strong CYP2C9 inhibitors combined with CYP3A4 inhibition.
What this interaction means in plain words
Ibuprofen and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Siponimod belongs to Central Nervous System.
Why it happens
Possible weak CYP2C9 competition; no established clinically significant inhibition of siponimod metabolism.
What to do
No dose change is needed. Monitor heart rate and lymphocyte counts per standard siponimod monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Ibuprofen with Siponimod?
MediHelp rates the interaction as minor. Ibuprofen and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibuprofen is a substrate and weak inhibitor of CYP2C9, so a clinically meaningful rise in siponimod exposure is unlikely. Siponimod interaction concerns are significant mainly with moderate or strong CYP2C9 inhibitors combined with CYP3A4 inhibition.
How serious is the interaction between Ibuprofen and Siponimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor heart rate and lymphocyte counts per standard siponimod monitoring.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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