Drug interactions
Ibuprofen + Streptomycin
Severity: Moderate
Ibuprofen and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and may raise aminoglycoside concentrations, mainly documented in preterm infants given indomethacin or ibuprofen. This could increase the risk of ototoxicity and nephrotoxicity.
What this interaction means in plain words
Ibuprofen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins lowers renal perfusion and glomerular filtration, reducing aminoglycoside clearance.
What to do
Monitor renal function and streptomycin serum concentrations, especially in neonates, the elderly or dehydrated patients, and adjust the aminoglycoside dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ibuprofen and Streptomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Ibuprofen with Streptomycin?
MediHelp rates the interaction as moderate. Ibuprofen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and may raise aminoglycoside concentrations, mainly documented in preterm infants given indomethacin or ibuprofen. This could increase the risk of ototoxicity and nephrotoxicity.
How serious is the interaction between Ibuprofen and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin serum concentrations, especially in neonates, the elderly or dehydrated patients, and adjust the aminoglycoside dose accordingly.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
