Drug interactions
Ibuprofen + Tolmetin
Severity: Major
Ibuprofen and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together increases the risk of gastrointestinal bleeding and ulceration, kidney injury and hyperkalemia without improving pain relief.
What this interaction means in plain words
Ibuprofen and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibuprofen belongs to Musculoskeletal; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition reducing gastroprotective and renal prostaglandins and platelet aggregation.
What to do
Avoid combining the two; use a single NSAID at the lowest effective dose. Add paracetamol or another non-NSAID option if more analgesia is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Ibuprofen with Tolmetin?
MediHelp rates the interaction as major. Ibuprofen and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together increases the risk of gastrointestinal bleeding and ulceration, kidney injury and hyperkalemia without improving pain relief.
How serious is the interaction between Ibuprofen and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two; use a single NSAID at the lowest effective dose. Add paracetamol or another non-NSAID option if more analgesia is needed.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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