Drug interactions
Ibuprofen + Valganciclovir
Severity: Minor
Ibuprofen and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may compete with ganciclovir, the active form of valganciclovir, for renal tubular secretion, which could raise ganciclovir exposure. The clinical importance is uncertain, though NSAIDs can also worsen renal function, which would further impair ganciclovir clearance.
What this interaction means in plain words
Ibuprofen and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Competition for renal tubular secretion via organic anion transporters and possible NSAID-related reduction in renal function.
What to do
Monitor renal function and blood counts for signs of ganciclovir toxicity such as cytopenias, particularly in patients with reduced creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Ibuprofen with Valganciclovir?
MediHelp rates the interaction as minor. Ibuprofen and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibuprofen may compete with ganciclovir, the active form of valganciclovir, for renal tubular secretion, which could raise ganciclovir exposure. The clinical importance is uncertain, though NSAIDs can also worsen renal function, which would further impair ganciclovir clearance.
How serious is the interaction between Ibuprofen and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts for signs of ganciclovir toxicity such as cytopenias, particularly in patients with reduced creatinine clearance.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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