Drug interactions
Ibuprofen / famotidine + Linagliptin-metformin
Severity: Minor
Ibuprofen / famotidine and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine is renally secreted by cationic transporters and may modestly raise metformin exposure. Ibuprofen can impair renal function in susceptible patients, which could further reduce metformin elimination. The effect is usually small in patients with normal kidney function.
What this interaction means in plain words
Ibuprofen / famotidine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular cationic transport (OCT2/MATE) and NSAID-related reduction in renal perfusion.
What to do
Monitor renal function and watch for signs of metformin accumulation in patients with renal impairment or dehydration. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Ibuprofen / famotidine with Linagliptin-metformin?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine is renally secreted by cationic transporters and may modestly raise metformin exposure. Ibuprofen can impair renal function in susceptible patients, which could further reduce metformin elimination. The effect is usually small in patients with normal kidney function.
How serious is the interaction between Ibuprofen / famotidine and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for signs of metformin accumulation in patients with renal impairment or dehydration. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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