Drug interactions
Ibuprofen / famotidine + Mesalamine
Severity: Minor
Ibuprofen / famotidine and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some oral mesalamine products use pH-dependent coatings to release drug in the distal gut. Famotidine raises gastric pH, which could cause premature release from certain formulations and alter delivery. Separately, NSAIDs such as ibuprofen have been linked to renal injury, which is also a recognized rare effect of mesalamine.
What this interaction means in plain words
Ibuprofen / famotidine and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Famotidine-related increase in gastric pH may alter release of pH-dependent mesalamine formulations, and both mesalamine and NSAIDs can be nephrotoxic.
What to do
Monitor renal function periodically and review colitis symptoms; consider a non-pH-dependent mesalamine formulation if acid suppression is long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Ibuprofen / famotidine with Mesalamine?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some oral mesalamine products use pH-dependent coatings to release drug in the distal gut. Famotidine raises gastric pH, which could cause premature release from certain formulations and alter delivery. Separately, NSAIDs such as ibuprofen have been linked to renal injury, which is also a recognized rare effect of mesalamine.
How serious is the interaction between Ibuprofen / famotidine and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically and review colitis symptoms; consider a non-pH-dependent mesalamine formulation if acid suppression is long term.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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