Drug interactions
Ibuprofen / famotidine + Mifepristone
Severity: Minor
Ibuprofen / famotidine and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone prolongs the QT interval, and famotidine has been associated with QT prolongation, particularly in renal impairment. Combined use may add some arrhythmic risk. Ibuprofen has no meaningful QT effect.
What this interaction means in plain words
Ibuprofen / famotidine and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive QT prolongation, mainly from the famotidine component.
What to do
Monitor ECG in patients with renal impairment, cardiac disease or electrolyte abnormalities. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ibuprofen / famotidine with Mifepristone?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone prolongs the QT interval, and famotidine has been associated with QT prolongation, particularly in renal impairment. Combined use may add some arrhythmic risk. Ibuprofen has no meaningful QT effect.
How serious is the interaction between Ibuprofen / famotidine and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with renal impairment, cardiac disease or electrolyte abnormalities. Correct potassium and magnesium abnormalities.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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