Drug interactions
Ibuprofen / famotidine + Saxagliptin-metformin
Severity: Minor
Ibuprofen / famotidine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine and other H2 blockers are renally secreted by cationic transporters and may modestly raise metformin levels. NSAIDs such as ibuprofen can impair renal function, which can raise metformin exposure and the risk of lactic acidosis in susceptible patients.
What this interaction means in plain words
Ibuprofen / famotidine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular cation transport and NSAID-related reduction in renal perfusion decrease metformin clearance.
What to do
Monitor renal function in at-risk patients, such as the elderly or those with kidney disease, and limit NSAID duration. Reduce the metformin dose if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Ibuprofen / famotidine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine and other H2 blockers are renally secreted by cationic transporters and may modestly raise metformin levels. NSAIDs such as ibuprofen can impair renal function, which can raise metformin exposure and the risk of lactic acidosis in susceptible patients.
How serious is the interaction between Ibuprofen / famotidine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in at-risk patients, such as the elderly or those with kidney disease, and limit NSAID duration. Reduce the metformin dose if renal function declines.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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