Drug interactions
Ibuprofen / famotidine + Tolbutamide
Severity: Minor
Ibuprofen / famotidine and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may modestly potentiate sulfonylurea effect, while famotidine has no meaningful effect on tolbutamide. The gastric pH rationale is not clinically relevant.
What this interaction means in plain words
Ibuprofen / famotidine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ibuprofen may displace tolbutamide from protein binding; the effect of famotidine is negligible.
What to do
Monitor blood glucose when the combination is started. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Ibuprofen / famotidine with Tolbutamide?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibuprofen may modestly potentiate sulfonylurea effect, while famotidine has no meaningful effect on tolbutamide. The gastric pH rationale is not clinically relevant.
How serious is the interaction between Ibuprofen / famotidine and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the combination is started. No routine dose change is needed.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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