Drug interactions
Ibutilide + Indapamide
Severity: Major
Ibutilide and Indapamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide has a substantial risk of torsades de pointes, which is increased by hypokalemia and hypomagnesemia. Indapamide can cause both disturbances.
What this interaction means in plain words
Ibutilide and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibutilide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte depletion.
What to do
Correct potassium and magnesium before ibutilide and monitor ECG continuously during and after infusion. Hold indapamide around the procedure where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Indapamide?
MediHelp rates the interaction as major. Ibutilide and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide has a substantial risk of torsades de pointes, which is increased by hypokalemia and hypomagnesemia. Indapamide can cause both disturbances.
How serious is the interaction between Ibutilide and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before ibutilide and monitor ECG continuously during and after infusion. Hold indapamide around the procedure where feasible.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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