Drug interactions
Amiodarone + Ibutilide
Severity: Contraindicated
Amiodarone and Ibutilide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are class III antiarrhythmics that prolong repolarization. Together they raise the risk of prolonged refractoriness, marked QT prolongation and torsades de pointes.
What this interaction means in plain words
Amiodarone and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Ibutilide belongs to Cardiovascular.
Why it happens
Additive blockade of cardiac potassium channels causing QT prolongation.
What to do
Do not give ibutilide to patients on amiodarone, nor other class III agents during or soon after the infusion. Use electrical cardioversion or another option.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Ibutilide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Ibutilide
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dronedarone + Ibutilide Contraindicated
Frequently asked questions
Can I take Amiodarone with Ibutilide?
MediHelp rates the interaction as contraindicated. Amiodarone and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are class III antiarrhythmics that prolong repolarization. Together they raise the risk of prolonged refractoriness, marked QT prolongation and torsades de pointes.
How serious is the interaction between Amiodarone and Ibutilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ibutilide to patients on amiodarone, nor other class III agents during or soon after the infusion. Use electrical cardioversion or another option.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
