Drug interactions
Icosapent + Indomethacin
Severity: Moderate
Icosapent and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl can slightly prolong bleeding time, and indomethacin impairs platelet function and irritates the gastric mucosa. Used together they may modestly increase bleeding risk.
What this interaction means in plain words
Icosapent and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects from omega-3 mediated reduction in platelet aggregation and NSAID cyclooxygenase inhibition.
What to do
Monitor for signs of bleeding, especially if anticoagulants or antiplatelets are also used. Consider gastroprotection in patients with GI risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Icosapent with Indomethacin?
MediHelp rates the interaction as moderate. Icosapent and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Icosapent ethyl can slightly prolong bleeding time, and indomethacin impairs platelet function and irritates the gastric mucosa. Used together they may modestly increase bleeding risk.
How serious is the interaction between Icosapent and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, especially if anticoagulants or antiplatelets are also used. Consider gastroprotection in patients with GI risk factors.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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