Drug interactions
Icosapent + Ketoprofen
Severity: Minor
Icosapent and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl can modestly prolong bleeding time and may add to the antiplatelet effects and gastrointestinal bleeding risk of NSAIDs. Clinically important bleeding is infrequent but labeling advises monitoring.
What this interaction means in plain words
Icosapent and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive platelet inhibition from omega-3 fatty acid and NSAID COX-1 inhibition.
What to do
Monitor periodically for bleeding signs, especially in patients with prior GI bleeding or on other antithrombotic agents.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Icosapent with Ketoprofen?
MediHelp rates the interaction as minor. Icosapent and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icosapent ethyl can modestly prolong bleeding time and may add to the antiplatelet effects and gastrointestinal bleeding risk of NSAIDs. Clinically important bleeding is infrequent but labeling advises monitoring.
How serious is the interaction between Icosapent and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor periodically for bleeding signs, especially in patients with prior GI bleeding or on other antithrombotic agents.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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