Drug interactions
Icosapent + Sulindac
Severity: Moderate
Icosapent and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may prolong bleeding time, and sulindac impairs platelet function and can cause gastrointestinal ulceration. Concurrent use may modestly increase bleeding risk.
What this interaction means in plain words
Icosapent and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects of omega-3 fatty acid and NSAID cyclooxygenase inhibition.
What to do
Monitor for signs of bleeding during combined use. Minimize NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Icosapent with Sulindac?
MediHelp rates the interaction as moderate. Icosapent and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Icosapent ethyl may prolong bleeding time, and sulindac impairs platelet function and can cause gastrointestinal ulceration. Concurrent use may modestly increase bleeding risk.
How serious is the interaction between Icosapent and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding during combined use. Minimize NSAID dose and duration.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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