Drug interactions
Icosapent + Warfarin
Severity: Moderate
Icosapent and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may modestly prolong bleeding time, and bleeding events have been somewhat more frequent with concomitant anticoagulants. Clinically significant INR changes are uncommon.
What this interaction means in plain words
Icosapent and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Omega-3 effects on platelet function add to anticoagulant-related bleeding risk.
What to do
Monitor for bleeding and check INR periodically during therapy, adjusting warfarin only if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Icosapent with Warfarin?
MediHelp rates the interaction as moderate. Icosapent and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Icosapent ethyl may modestly prolong bleeding time, and bleeding events have been somewhat more frequent with concomitant anticoagulants. Clinically significant INR changes are uncommon.
How serious is the interaction between Icosapent and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check INR periodically during therapy, adjusting warfarin only if needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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