Drug interactions
Idarubicin + Paclitaxel
Severity: Moderate
Idarubicin and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel given with anthracyclines has been associated with greater cardiotoxicity, mainly shown with doxorubicin, and the effect with idarubicin is extrapolated. Sequence and cumulative anthracycline dose influence the risk.
What this interaction means in plain words
Idarubicin and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idarubicin belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Paclitaxel may reduce anthracycline clearance and promote formation of cardiotoxic metabolites, with additive myelosuppression.
What to do
Monitor cardiac function (LVEF) and blood counts, and give the anthracycline before paclitaxel where the regimen allows.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Idarubicin with Paclitaxel?
MediHelp rates the interaction as moderate. Idarubicin and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel given with anthracyclines has been associated with greater cardiotoxicity, mainly shown with doxorubicin, and the effect with idarubicin is extrapolated. Sequence and cumulative anthracycline dose influence the risk.
How serious is the interaction between Idarubicin and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cardiac function (LVEF) and blood counts, and give the anthracycline before paclitaxel where the regimen allows.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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